Volume Vol 1 Issue # 1

Environment-wide reprogramming of total RNA abundance and metabolic processes by Glutamate dehydrogenase-synthesized RNA enzyme: Terminologies for the New RNAs.

Godson O. Osuji*^, Remigius N. Okea^
Date Received October 23. 2024
Date Accepted November 21. 2024

Abstract

In the beginning, the biological role of hexameric isoenzymes of NADH-glutamate dehydrogenase (GDH) was described in enzyme kinetics as the signal integration and discrimination function of the enzyme. But with the discovery of the RNA synthetic activity and the understanding of the properties and the chemical mechanisms of the new RNA (chimerenomic RNA: refer to the Appendix for the new terminologies) in aligning all the cellular and metabolic processes with the changes in the environmental conditions, it became abundantly imperative that chimerenomic RNA could not be described with the terminologies of genetics and genomics. The new RNAs (chimeres and NTintis) differentially degrade superfluous mRNAs, rRNAs, transfer RNAs etc homologous to them when there are physicochemical changes in the environment; the changes in the total RNA abundances are then followed by reprogramming of the physiological processes of growth, differentiation, respiration, cell death, drug catabolism, drought and pest resistance etc so that the cell, tissue, whole organism achieves equilibrium of survival within the available resources in its environment.  The function of NADH-GDH hexameric redox cycle isoenzymes (GDH-chigramming) is to convert the diverse physicochemical changes of the environment to an electromagnetic molecular dataset, the nucleotide sequences of chimerenomic RNA enzyme. This capability is embedded in the subunit compositions and their 3-D conformations in the GDH hexameric isoenzymes. The energy involved in the conversion of the genetic information in total RNA (mRNA, rRNA, transfer RNA) to another electromagnetic dataset, the amino acid sequences of proteins is of comparable biological importance and significance as the conversion of the environment-wide physicochemical energy changes of cells, tissues, whole organism to another electromagnetic molecular dataset, the nucleotide sequences of chimerenomic RNAs. This review updates the recent advances in the differential control of the abundances of total RNA by environment-mediated changes in GDH molecular chemistry; and interjects some of the new terminologies therefrom for describing the new RNAs. It shows that the chemistry of GDH unleashes into a new domain order of the life sciences, new medicine, new pharmacology, new molecular biology etc for the improvement and consolidation of human disease management, treatment, primary care, welfare, and economics.

*Corresponding author (GOO) email: osujigodson99@gmail.com Formerly at Prairie View A&M University, Prairie View, Texas. ^ American Academy of Primary Care Research (AAPCR), San Antonio, Texas

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